Stan M. Hollenberg, Ph.D.

Patent Agent

Stan Hollenberg, Ph.D., is a registered patent agent with strong experience in biotechnology and medical devices. His practice at Kolisch Hartwell includes extensive experience preparing and prosecuting U.S. and foreign patent applications. His decade of post-graduate research experience includes directing a laboratory as a principal investigator and training as a postdoctoral fellow in two other laboratories. Stan’s science background allows him to assist clients in a wide range of patentable technologies. His experience in molecular biology, cell biology, genetics, and biochemistry has been particularly helpful for clients in the biotechnological and medical disciplines.

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Experience

Before joining Kolisch Hartwell in 2000, Stan gained more than ten years of post-graduate research experience in the biological sciences. Between 1995 and 2000, he was a principal investigator at Oregon Health & Science University (OHSU), while studying mechanisms of gene memory. Between 1988 and 1995, he conducted postdoctoral research with two members of the National Academy of Sciences, including studies at the Salk Institute on nuclear receptors and at the Fred Hutchinson Cancer Research Center on master regulatory genes. He has co-authored more than 25 peer-reviewed publications and is a co-inventor on 11 U.S. patents.<

Education

Ph.D. Biology – 1988

University of California at San Diego Kamen prize for outstanding Biochemistry dissertation<

B.A. Chemistry, magna cum laude – 1979

Pomona College Stanley D. Wilson Prize for outstanding Chemistry graduate

Bar Admissions
  • U.S. Patent and Trademark Office (USPTO), 2001

Selected Publications

  • Smith, R. N., and Hollenberg, S. (1978). Lack of confirmation for conformational changes in papain caused by ligand binding. Physiol. Chem. & Physics. 10, 557–559.
  • Steinmetz, W. E., Pollard, J. E., Blaney, J. M., Winker, B. K., Mun, I. K., Hickernell, F. J., and Hollenberg, S. M. (1979). Conformational analysis of conjugated polyenes by nuclear magnetic resonance and low resolution microwave spectroscopy. J. Phys. Chem. 83, 1540–1545.
  • Hollenberg, S. M., Chappell, T. G., Purves, W. K. (1981). High performance liquid chromatography of amino acid conjugates of indole-3-acetic acid. J. Agr. Food Chem. 29, 1173–1174.
  • Purves, W. K., and Hollenberg, S. M. (1982). Metabolism of exogenous indoleacetic acid to its amide conjugates in Cucumis sativus L. Plant Physiol. 70, 283–286.
  • Hollenberg, S. M., Lai, J. S., Weickmann, J. L., and Date, T. (1984). Primer-directed mutagenesis of linearized plasmids. Anal. Biochem. 143, 341–349.
  • Weinberger, C., Hollenberg, S. M., Ong, E. S., Harmon, J. M., Brower, S. T., Cidlowski, J., Thompson, E. B., Rosenfeld, M. G., and Evans, R. M. (1985). Identification of human glucocorticoid receptor complementary DNA clones by epitope selection. Science 228, 740–742.
  • Hollenberg, S. M., Weinberger, C., Ong, E. S., Cerelli, G., Oro, A., Lebo, R., Thompson, E. B., Rosenfeld, M. G., and Evans, R. M. (1985). Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318, 635–641.
  • Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G., and Evans, R. M. (1985). Domain structure of human glucocorticoid receptor and its relationship to the v erb A oncogene product. Nature318, 670–672.
  • Giguère, V., Hollenberg, S. M., Rosenfeld, M. G., and Evans, R. M. (1986). Functional domains of the human glucocorticoid receptor. Cell 46, 645–652.
  • Hollenberg, S. M., Giguère, V., Segui, P., and Evans, R. M. (1987). Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell 49, 39–46.
  • Pratt, W. B., Jolly, D. J., Pratt, D. V., Hollenberg, S. M., Giguère, V., Cadepond, F. M., Schweizer Groyer, G., Catelli, M. G., Evans, R. M., Baulieu, E. E. (1988). A region in the steroid binding domain determines formation of the non DNA binding, 9 S glucocorticoid receptor complex. J. Biol. Chem. 263, 267 273.
  • Evans, R. M., and Hollenberg, S. M. (1988). Zinc fingers: gilt by association. Cell 52, 1–3.
  • Lee, J. -H., Weickmann, J. L., Koduri, R. K., Ghosh-Dastidar, P., Saito, K., Blair, L. C., Date, T., Lai, J. S., Hollenberg, S. M., and Kendall, R. L. (1988). Expression of synthetic thaumatin genes in yeast. Biochem. 27, 5101–5107.
  • Hollenberg, S. M., and Evans, R. M. (1988). Multiple and cooperative trans activation domains of the human glucocorticoid receptor. Cell 55, 899–906.
  • Oro, A. E., Hollenberg, S. M., and Evans, R. M. (1988). Transcriptional repression by a glucocorticoid receptor β galactosidase fusion protein. Cell 55, 1109–1114.
  • Becker, D. M., Hollenberg, S. M., and Ricciardi, R. P. (1989). Fusion of adenovirus E1A to the glucocorticoid receptor by high-resolution deletion cloning creates a hormonally inducible viral transactivator. Mol. Cell. Biol. 9, 3878–3887.
  • Theriault, A., Boyd, E., Harrap, S. B., Hollenberg, S. M., and Connor, J. M. (1989). Regional chromosomal assignment of the human glucocorticoid receptor gene to 5q31. Human Genetics 83, 289–291.
  • Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M. Benezra, R., Blackwell, T. K., Turner, D., Rupp, R., Hollenberg, S., Zhuang, Y., and Lassar, A. (1991). The MyoD gene family: nodal point during specification of the muscle cell lineage. Science 251, 761–766.
  • Cadepond, F., Schweizer-Groyer, G., Segard-Maurel, I., Jibard, N., Hollenberg, S. M., Giguere, V., Evans, R. M., Baulieu, E. E. (1991). J. Biol. Chem. 266, 5834–5841.
  • Weintraub, H., Dwarki, V. J., Verma, I., Davis, R., Hollenberg, S., Snider, L., Lassar, A., and Tapscott, S. J. (1991). Muscle-specific transcriptional activation by MyoD. Genes & Dev. 5, 1377–1386.
  • Vojtek, A. B., Hollenberg, S.M., and Cooper, J. A. (1993). Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205–214.
  • Hollenberg, S. M., Cheng, P. F., and Weintraub, H. (1993). Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination. Proc. Natl. Acad. Sci. USA90, 8028–8032.
  • Hollenberg, S.M., Sternglanz, R., Cheng, P.F., and Weintraub, H. (1995). Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two hybrid system. Mol. Cell. Biol. 15, 3815–3822.
  • Lee, J.E., Hollenberg, S.M., Snider, L., Turner, D.L., Lipnick, N., and Weintraub, H. (1995). Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268, 836–844.
  • Vojtek, A.B., Hollenberg, S.M. (1995). Ras-Raf interaction: two-hybrid analysis. Methods Enzymol. 255, 331–342.
  • Shih, H-M., Goldman, P.S., DeMaggio, A.J., Hollenberg, S.M., Goodman, R.H., and Hoekstra, M.F. (1996). A positive genetic selection for disrupting protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP. Proc. Natl. Acad. Sci. USA. 93, 13896–13901.
  • Yoshitake, Y., Howard, T.L., Christian, J.L., and Hollenberg, S.M. (1999). Misexpression of Polycomb-Group proteins in Xenopus alters anterior neural development and represses neural target genes. Dev. Biol. 215, 375-387.
  • Stauffer, D.R., Howard, T.L., Nyun, T., and Hollenberg, S.M. (2001). CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression. J. Cell Sci. 114, 2383–2393.
  • Howard, T.L., Stauffer, D.R., Degnin, C., and Hollenberg, S.M. (2001). CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. J. Cell Sci. 114, 2395–2404.

Patents Naming Stan Hollenberg as Inventor

Patent Number
Issued
Title
1991
Hormone receptor-related bioassays
1993
Receptors: their identification, characterization, preparation and use
1993
Receptors: their identification, characterization, preparation and use
1994
Bioassay for identifying ligands for steroid hormone receptors
1994
Receptors: their identification, characterization, preparation and use
1994
Hormone receptor compositions and methods
1996
Controlled expression of recombinant proteins
1996
Receptor transcription-repression activity compositions and methods
5,597,705
1997
DNA encoding thyroid hormone receptor compositions and methods
1997
Dominant negative chimeras of the steroid/thyroid superfamily of receptors
1997
Neurogenic differentiation (neurod) genes